MRI/S-DNP: 5T Dynamic Nuclear Polarization

AMRIS Facility’s dissolution DNP utilizes a 5 T magnet in which samples are cooled to <1.1 K. With microwave irradiation, we achieve 70% polarization of 13C nuclei in the polarizer; this translates to a >14,000 gain in SNR on dissolution and injection into an MRI/S scanner. The custom design of the polarizer enables the use of dissolution DNP to study metabolic flux in vivo using a variety of NMR–active nuclei as well as the study of fundamental mechanisms of polarization enhancement. This polarizer is available to external users through the MagLab.